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Clinical Pharmacokinetics and Pharmacodynamics
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Table of Contents

Preface

Definition of Symbols

Non-Proprietary and Brand Names of Drugs in Text and Illustrations

I. Basic Considerations
1. Therapeutic Relevance
2. Fundamental Concepts and Terminology

II. Exposure and Response after a Single Dose
3. Kinetics Following an Intravenous Bolus Dose
4. Membranes and Distribution
5. Elimination
6. Kinetics Following an Extravascular Dose
7. Absorption
8. Response Following a Single Dose

III. Therapeutic Regimens
9. Therapeutic Window
10. Constant-Rate Input
11. Multiple Dose Regimens

IV. Individualization
12.Variability
13.Genetics
14. Age, Weight, and Gender
15. Disease
16. Nonlinearities
17. Drug Interactions
18. Initiating and Managing Therapy

V. Supplemental Topics
19. Distribution Kinetics
20. Metabolites and Drug Response
21. New! Protein Drugs
22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data

Appendices
A. Assessment of AUC
B. Ionization and the pH Partition Hypothesis
C. Distribution of Drugs Extensively Bound to Plasma Proteins
D. Plasma-to-Blood Concentration Ratio
E. Well-stirred Model of Hepatic Clearance
F. Absorption Kinetics
G. Wagner-Nelson Method
H. Mean Residence Time
I. Amount of Drug in Body on Accumulation to Plateau
J. Answers to Study Problems

Reviews

-- "This textbook covers a tremendous range of topics important in pharmacokinetics and pharmacodynamics. No other textbook does this as effectively as the Rowland and Tozer text." -- "I believe this book is the best written text for bridging the gap between basic PK and clinical PK."

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