Table of Contents

• Introduction
• What Is Epilepsy?
• Resting Potential
• Action Potential
• Are There Any Genetic Bases for Epilepsy?
• Ligand-gated Ion Channels
• Acetylcholine Receptors CHRNA4, CHRNB2, and CHRNA2
• Ion Channels
• Sodium Channels
• Potassium Channel Subunit Mutations with LOF Effects
• Voltage-gated Calcium Channel Mutations and Genetic Susceptibility
• GABA Receptor Subunit Mutations (Chloride Channel)
• Copy Number Variants and Comorbidities
• Susceptibility Genes for Complex Epilepsy
• Glycine Receptors
• Ionotropic Glutamate Receptors
• G-protein-coupled Receptors
• Metabotropic Glutamate Receptors
• Other Genetic Causes of Epilepsy
• Mitochondrial Inheritance and Myoclonic Epilepsy with Ragged Red Fibers
• Leucine-rich Glioma Inactivated Gene 1 (LGI1)
• Inborn Errors of Metabolism and Epilepsy
• Epilepsy and NMDs
• FOLR1 Gene Mutation
• Lysosomal Storage Disorders
• The Solute-carrier Gene Superfamily and Epilepsy
• Genes Related with Different Epileptic Syndromes
• Genetic Mechanisms of Drug Resistance in Epilepsy
• Definition of Drug Resistance in Epilepsy
• Genetics of Drug Response in Epilepsy
• Drug Transport System
• ABC Transporters
• ABC Transporters and RE
• MDR1 (ABCB1) Gene Variants
• The BBB's Role in Pharmacoresistance in Epilepsy
• Induction of ABC Transporters: Is the Acquired Refractoriness an Inducible Process?
• Genes and Pharmacodynamic Modifications
• Inducing the Expression of P-gp in Neurons: Is it to Induce Epileptogenesis?
• References
• Author Biographies