What is molecular biology? How does it relate to cell biology and biochemistry. Cancer genetics. What are cancer genes? How are cancer genes mutated? Hereditary predisposition and gene discovery. Important chromosomal translocations in cancer. Signal transduction and cancer. GTP-binding proteins and cancer. Cell cycle controls and cancer. Viruses and human cancer. Cell adhesion, motility and cancer. Differentiation and cancer. Multistage carcinogenesis. Chromatin structure and nuclear function. Genomic instability and cancer. Strategies for cancer prevention and cure. Opportunities for genetic counselling. Molecular basis of radiation sensitivity. How do cells repair DNA damage by radiation? Radiation-induced cytokines and growth factors. Chemotherapeutic drug-induced DNA damage and repair. Molecular basis of drug resistance. Drug discovery and cancer genetics. The molecular biology of endocrine responsiveness in breast cancer. Apoptosis as a therapeutic target. Tumour angiogenesis as a therapeutic target. Antibody technology is being transformed. Strategies for gene therapy of cancer. Prodrug therapies. Oligonucleotide therapies.
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