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Table of Contents

1. Clearance

2. Volume of distribution 3. Half-Life 4. How Drugs are Cleared by the Liver 5. Bioavailability and First-Class Clearance 6. Predicting Drug Interactions and the Effects of Disease States for Metabolised Drugs 7. Clearance of Drugs by the Kidneys 8. Drug Protein Binding 9. Non-Linear Pharmacokinetics 10. How to Determine the Pharmacokinetic Parameters of a Drug 11. Pharmacodynamics - the Concentration-Effect Relationship 12. Designing Dose Regimens 13. Therapeutic Drug Monitoring

About the Author

Donald Birkett Professor and Head of Clinical Pharmacology, Flinders University, SA; has chaired the Australian Drug Utilisation Subcommittee and the WHO Working Group on Drug Statistics Methodology.

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