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Practical Cardio-Oncology


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Table of Contents

Table of Contents

Section I: Introduction

Chapter 1: Cardio-Oncology: How a new discipline arrived. Susan Dent MD, FRCPC, Nestor Gahungu MD, Moira Rushton, MD, FRCPC, Josee Ivars BSc, Carlo Cippola MD, Daniel Lenihan, MD, FACC Section II: Clinical Aspects of Cardio-Oncology Chapter 2: Current Imaging Strategies in Cardio-Oncology Mirela Tuzovic MD, Melkon Hacobian MD and Eric Yang, MD Chapter 3: Approach to Risk Stratification in Cardio-Oncology Christopher B. Johnson, Gary Small, Angeline Law, Habibat Garuba Chapter 4: Overview of Changes in Cancer Treatment Strategies Grace Tang Msc, Christine Brezden-Masley MD, PhD, FRCPC Chapter 5: Radiotherapy for Cancer Patients Girish Kunapareddy, Adarsh Sidda, Christopher Fleming, Chirag Shah, Patrick Collier Chapter 6: Overview of Current Guidelines in Cardio-Oncology Felicity Lee and Girish Dwivedi Chapter 7: Prevention Strategies in Cardio-Oncology Carolina Maria Pinto Domingues Carvalho Silva, Cristina Salvadori Bittar, Marilia Harumi Higuchi dos Santos, Ludhmila Abrahao Hajjar Chapter 8: Survivorship (1): Cancer and Cardiovascular Disease Michael Chetrit, MD, FRCPC, Sabin Filmon MD, Nina Ghosh MD*, FRCPC, Negar Mousaavi MD, FRCPC, FACC* Chapter 9: Survivorship (2): Pediatric Cancer Survivors Shahnawaz Amdani, MBBS, MD, Neha Bansal MD, Emma R. Lipshultz, M. Jacob Adams MD, MPH, Steven E. Lipshultz MD Chapter 10: Cardio-Oncology Case Studies Case 1: Gregory R. Hartlage, Palmar H. Cole, Aarti A. Patel, Alberto Morales, Anita Radhakrishnan, Eric E. Harrision Case 2: Anita Radhakrishnan, Eric E. Harrison Case 3: Hassan Tariq, Shetal Amin, Milee Singh, Cesar Alberto Morales-Pabon MD, Kristina Cahill, Anita Radhakrishnan, Eric E. Harrision Section III: The Cardio-Oncology Clinic Chapter 11: Establishing a Cardio-Oncology Clinic Susan Dent MD, FRCPC , Moira Rushton, MD, FRCPC, Josee Ivars BSc, Heather Lounder, Joyce Botros MD, Joerg Herrmann MD Chapter 12: Cardio-Oncology Training Sarju Ganatra, MD and Michael G. Fradley, MD Chapter 13: Cardio-Oncology Nursing Anecita Fadol, PhD Chapter 14: Treating the Cardio-Oncology Patient Sebastian Szmit, MD Section IV: The Future of Cardio-Oncology Chapter 15: Future Research in Cardio-Oncology Li Ling Yan MD, Sean Zheng MD, Alexander R Lyon MD Chapter 16: Cardio-Oncology: Future Directions in Clinical Care and Education Susan Dent MD, FRCPC, Gretchen Kimmick MD, MS and Joe Carver MD

About the Author

Dr. Dent is a medical oncologist and Professor of Medicine, at Duke University in Durham, North Carolina, U.S.A. She is Associate Director of Breast Cancer Clinical research, and Co-Director of the Cardio-Oncology program at Duke University. Dr. Dent attended McMaster medical school in Hamilton, Ontario, Canada and completed her residency training in Internal Medicine and Medical Oncology at the Ottawa Hospital, University of Ottawa, Ottawa, Canada. She subsequently completed a post-graduate research fellowship in clinical trials at the Canadian Cancer Trials Group (CCTG) in Kingston, Ontario, and in 1996 was appointed as a staff medical oncologist at the Northwestern Ontario Cancer Center in Thunder Bay, Ontario. In 2001, Dr. Dent returned to The Ottawa Hospital Cancer Center, where she specialized in breast cancer oncology. Dr. Dent held several leadership positions, in Ottawa including, Director of Clinical Trials, Vice Chair of Patient Quality and Safety in the Department of Medicine and Co-Chair of the Ontario Cancer Research Ethics Board (OCREB). In 2008, Dr. Dent, working with her cardiology colleagues, established a multidisciplinary cardio-oncology clinic in Ottawa- the first of its kind in Canada. Subsequently, she founded the Canadian Cardiac Oncology Network (CCON) in 2011, a not-for-profit organization devoted to optimization of cancer care for patients without compromising cardiovascular health. Yearly CCON meetings in Ottawa helped facilitate the establishment of cardio-oncology clinics across Canada, as did the launch of a website (www.cardiaconcology.ca). In 2015, she launched the Global Cardio-Oncology Summit (GCOS), an annual meeting which now attracts oncologists, cardiologists, and allied health care providers from around the world. Dr. Dent is recognized as a global leader in cardio-oncology. She has travelled extensively around the world (China, India, Europe, North and South America), as an invited speaker, sharing her knowledge and expertise on the potential impact of cancer treatment on cardiovascular health. She has published extensively in this area and has co-authored a number of position statements and clinical practice guidelines. She is an Associate Editor of Cardio-Oncology, the first dedicated peer reviewed journal in this new discipline. She continues to work and build relationships with global organizations interested in cardio-oncology including: European Society of Cardiology, American College of Cardiology and the American Society of Clinical Oncology. Dr. Dent currently serves as an Executive Officer of the International Cardio-Oncology Society (ICOS), an organization dedicated to bringing cardiologists, oncologists, and allied health care providers together, to improve the clinical care of patients and save lives. In September 2018, Dr. Dent accepted a position as staff medical oncologist at Duke University. In addition to establishing a breast cancer practice, she will continue her efforts in promoting clinical care, education and research in the evolving field of Cardio-Oncology.


This is a reader-friendly book that is a great resource for cardiologists, oncologists, and healthcare professionals, and outlines the assessment, monitoring, and management of cancer therapy-related cardiac complications using the most up-to-date guidelines and protocols. The coverage spans from prevention, monitoring, and treatment of cardiovascular toxicity of cancer treatments to cardiovascular care for cancer survivors. It also discusses preventive strategies for minimizing the risks of cancer therapy-related cardiovascular toxicities and future directions in cardio-oncology research.

Stephanie M. Madonis, M.D.(Ochsner Heart & Vascular Institute)

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