Preface XII Acknowledgments XIV Organizations Associated with the TNM System XV Members of UICC Committees Associated with the TNM System XVI Section Editors XVII Introduction 1 Head and Neck Tumours 17 Lip and Oral Cavity 18 Pharynx 22 Larynx 31 Nasal Cavity and Paranasal Sinuses 36 Unknown Primary - Cervical Nodes 40 Malignant Melanoma of Upper Aerodigestive Tract 45 Major Salivary Glands 47 Thyroid Gland 51 Digestive System Tumours 55 Oesophagus and Oesophagogastric Junction 57 Stomach 63 Small Intestine 67 Appendix 70 Colon and Rectum 73 Anal Canal and Perianal Skin 77 Liver 80 Intrahepatic Bile Ducts 83 Gallbladder 85 Perihilar Bile Ducts 87 Distal Extrahepatic Bile Duct 89 Ampulla of Vater 91 Pancreas 93 Well?Differentiated Neuroendocrine Tumours of the Gastrointestinal Tract 96 Lung, Pleural, and Thymic Tumours 105 Lung 106 Pleural Mesothelioma 113 Thymic Tumours 115 Tumours of Bone and Soft Tissues 119 Bone 120 Soft Tissues 124 Gastrointestinal Stromal Tumour (GIST) 127 Skin Tumours 131 Carcinoma of Skin 133 Skin Carcinoma of the Head and Neck 136 Carcinoma of Skin of the Eyelid 139 Malignant Melanoma of Skin 142 Merkel Cell Carcinoma of Skin 147 Breast Tumours 151 Gynaecological Tumours 159 Vulva 161 Vagina 164 Cervix Uteri 166 Uterus - Endometrium 171 Uterine Sarcomas 175 Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma 179 Gestational Trophoblastic Neoplasms 184 Urological Tumours 187 Penis 188 Prostate 191 Testis 195 Kidney 199 Renal Pelvis and Ureter 202 Urinary Bladder 204 Urethra 208 Adrenal Cortex 211 Ophthalmic Tumours 215 Carcinoma of Conjunctiva 216 Malignant Melanoma of Conjunctiva 218 Malignant Melanoma of Uvea 221 Retinoblastoma 226 Sarcoma of Orbit 230 Carcinoma of Lacrimal Gland 232 Hodgkin Lymphoma 235 Non?Hodgkin Lymphomas 239 Essential TNM 241 Paediatric Tumours 247 Gastrointestinal Tumours 247 Bone and Soft Tissue Tumours 248 Gynaecological Tumours 249 Urological Tumours 250 Ophthalmic Tumours 251 Malignant Lymphoma 252 Central Nervous System 252
James D. Brierley, BSc, MB, FRCP, FRCR, FRCPC Professor, Department of Radiation Oncology, Princess Margaret Cancer Centre and the University of Toronto, Canada Dr Brierley trained in Clinical Oncology in the UK and developed his interest in cancer staging and surveillance when moving to Canada and has been involved in cancer surveillance, locally, nationally and internationally. He is Co-Chair of the UICC TNM Prognostic Factors Project. He has co-edited the TNM Supplement 4th edition (Wiley 2012) and the UICC Manual of Clinical Oncology (Wiley 2015). Mary K. Gospodarowicz MD, FRCPC, FRCR (Hon) Medical Director, Princess Margaret Cancer Centre, University Health Network; Regional Vice-President of Cancer Care Ontario for Toronto South; Toronto, Ontario, Canada Dr Gospodarowicz is the Past-President of UICC. She has a long-standing interest in cancer classification with an emphasis on staging and prognostic factors and she has been involved in the UICC TNM Project for many years. Her interests include the application of modern information and communication technologies in cancer control. Dr Gospodarowicz was coeditor of the 7th edition of the TNM Classification of Malignant Tumours (Wiley 2009) and editor of the 2nd and 3rd editions of the UICC Prognostic Factors in Cancer (Wiley 2001, 2006). Christian Wittekind MD Professor of Pathology, Chairman Institute of Pathology, University of Leipzig, Germany Dr Wittekind been involved in cancer staging and tumour classifications for over 20 years. He is a member of the UICC TNM Core Committee, Head of the German Speaking TNM-Komittee, and personally responds to all the questions to the UICC TNM helpdesk. He was the coeditor of the 5th , 6th and 7th edition of the TNM classification of Malignant Tumours (Wiley 1997, 2002, 2009) editor of the 2nd, 3rd, and 4th edition of the TNM Supplement (Wiley 2001, 2003 and 2012) and editor of the 6th edition of the TNM Atlas (Wiley 2014).